The Denver Broncos and San Francisco 49ers meet in Week 4 with both teams carrying winning records into a matchup at Levi’s Stadium. Denver has won two of its first three games, while San Francisco has opened the season with three straight victories.
Sep 27, 2026; Denver, Colorado, USA; Denver Broncos quarterback Bo Nix (10) warms up before the game against the Los Angeles Rams at Empower Field at Mile High. Mandatory Credit: Ron Chenoy-Imagn Images
How to Watch Broncos vs 49ers
When: Sunday, October 4, 2026
Time: 4:25 PM ET
TV Channel: CBS
Live Stream: Fubo (try for free)
The Broncos enter the matchup relatively healthy, with outside linebacker Dondrea Tillman the only Denver player officially ruled out. J.K. Dobbins, Jaylen Waddle and Marvin Mims Jr. were all full participants in Friday’s practice and carry no game designation, giving Denver several important weapons for its attempt to keep pace with San Francisco.
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The 49ers have more injury concerns, particularly along their defensive front. Nick Bosa, Mykel Williams and James Thompson Jr. have all been ruled out, while Mike Evans and Dre Greenlaw are among the players listed as questionable. That could create opportunities for Denver’s offense against a San Francisco team that has overcome injuries to remain unbeaten through three weeks.
This is a great NFL matchup that you will not want to miss; make sure to tune in and catch all the action.
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